Langerin or CD207 is a type II transmembrane glycoprotein. It is used to mark the presence of Langerhans cells or LCs in the given sample. These cells signify the presence of immature dendritic cells present in the skin. LCs uniquely features tennis racket-shaped endosomal recycling compartment subdomains using pentalamellar membranes called Birbeck granules.
Langerin is an element for Birbeck granule formation. Trimerization significantly raises the lectin binding affinity. Langerin internalizes with endogenous proteins like type I procollagen. You can buy a high-quality cd207 antibody kit at https://www.bosterbio.com/anti-cd207-antibody-a02316-boster.html.
Internalization performed by LC is considered to result in suppression of self-responses. LCs also mediates endocytosis of non-peptide antigens comprising mannose, N-acetyl glucosamine, and fucose which are brought on by mycobacteria and fungi.
Langerin plays a barrier-like role in HIV-1 transmission because of its internalization of virus contamination for degradation. An uncommon human polymorphism inside the lectin abolishes both carbohydrate recognition and Birbeck granule formation. Langerin is consequently a powerful inducer of cartilage superimposition and zippering resulting in BG formation.
RMUL.2 is a monoclonal antibody that reacts with the predicted extracellular domain of mouse CD207, also referred to as Langerin. Mouse CD207 is extracted from a different subset of dendritic cells known as Langerhans cells. Mouse CD207 is a C-type lectin and putative transmembrane protein which probably plays a role in antigen recognition and uptake.